False negative antigliadin and antiendomysial antibodies in selective serum deficiency

In this study we report two cases of gluten enteropathy diagnosed by clinical hystory, small bowel biopsy and clinical improvement on a gluten-free diet. Both had elevated serum IgG-antigliadin antibodies and false negative serum IgA-antigliadin and antiendomysial antibodies. Determination of serum IgA facilitates the interpretation of unexpected negative antigliadin class IgA and antiendomysial antibodies.